Incidence, risk and prognosis of acute and chronic fatigue syndromes and psychiatric disorders after glandular fever. Acute infectious mononucleosis: characteristics of patients who report failure to recover.
Viral and non-viral pathogens precipitate post-infective and chronic fatigue syndromes: a prospective cohort study. Risk and predictors of fatigue after infectious mononucleosis in a large primary care cohort. The validity and reliability of the fatigue syndrome that follows glandular fever. The nosology of sub-acute and chronic fatigue syndromes that follow infectious mononucleosis.
Chronic fatigue syndrome and arthralgia following parvovirus B19 infection. Google Scholar PubMed. Recovery from infectious mononucleosis: a case for more than symptomatic therapy? A systematic review. Predictions and associations of fatigue syndromes and mood disorders that occur after infectious mononucleosis. Prolonged illness following EBV infection is associated with altered immunity but not elevated viral load.
Gene expression correlates of postinfective fatigue syndrome after infectious mononucleosis. Gene expression profile of empirically delineated classes of unexplained chronic fatigue. Potential conflicts of interest: none reported.
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Infectious Disease Physician. Senior Clinician. View all jobs. Assessed by noninvasive, continuous recordings of heart rate, blood pressures and stroke volume during supine rest. In particular blood and urine measurements of catecholamines and the HPA axis. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Microbiological laboratories serving the population of Oslo and neighbour conties.
Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. Layout table for location information Norway Dept. More Information. Predictors of chronic fatigue in adolescents six months after acute Epstein-Barr virus infection: A prospective cohort study.
Brain Behav Immun. Epub Sep National Library of Medicine U. That's because B- and T-cells, in a healthy immune system, remember the virus and can rapidly assemble an army of antibodies to keep it in check. If the immune system isn't working correctly, though, it could theoretically allow the virus to gain a foothold at levels that once again make you sick. When that happens, it's called reactivation. Research published in shores up that hypothesis.
In this study, scientists found evidence that the B- and T-cells of many people with this disease were unable to remember EBV, meaning a reactivated virus would be better able to thrive, reproduce, and cause symptoms.
Researchers found this impaired cellular memory in the immune systems of 76 percent of the more than study participants. That's an impressive percentage. EBV is a nasty bug. It's best known for causing infectious mononucleosis , which is frequently called mono or the "kissing disease. Recovery from mono is known to take a long time, and recurrences are marked by extreme fatigue. That has confounded attempts to explain how EBV could contribute to the illness.
This study appears to overcome that problem, though, providing an answer to that question. It doesn't answer questions about why some people's immune systems seem to be blind to this particular virus, though. That's a topic for future research, as is finding a way to fix the blindness.
It seems that the harder EBV hits, the more likely it is to cause prolonged illness. EBV may also play a role in multiple sclerosis. Some research also suggests it can mimic acute leukemia. None of this is conclusive, though. Get our printable guide for your next doctor's appointment to help you ask the right questions. Learn about treatment and lifestyle changes to cope with fibromyalgia and chronic fatigue syndrome. PLoS One. Can persistent Epstein-Barr virus infection induce chronic fatigue syndrome as a Pavlov reflex of the immune response?
J Biol Dyn. Chronic fatigue syndrome after infectious mononucleosis in adolescents.
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